Vivo Y33s is a 6.58-inch touchscreen display with a resolution of 1080×2408 pixels. The phone is powered by an octa-core MediaTek Helio G80 processor. It comes with 4GB of RAM. The Vivo Y33s runs Android 11 and is powered by a 5000mAh non-removable battery. The Vivo Y33s supports proprietary fast charging.

As far as the cameras are concerned, the Vivo Y33s on the rear packs a triple camera setup featuring a 50-megapixel primary camera with an f/1.8 aperture; a 2-megapixel camera with an f/2.4 aperture, and a 2-megapixel camera with an f/2.4 aperture. The rear camera setup has autofocus. It has a single front camera setup for selfies, featuring a 16-megapixel sensor with an f/2.0 aperture. The front camera also features autofocus.

The Vivo Y33s runs Funtouch OS 11.1 is based on Android 11 and packs 128GB of inbuilt storage that can be expanded via microSD card (up to 1000GB) with a dedicated slot. The Vivo Y33s is a dual-SIM (GSM and GSM) mobile that accepts Nano-SIM and Nano-SIM cards.

Connectivity options on the Vivo Y33s include Wi-Fi, GPS, Bluetooth v5.00, NFC, USB OTG, USB Type-C, 3G, and 4G. Sensors on the phone include accelerometer, ambient light sensor, compass/ magnetometer, proximity sensor, and fingerprint sensor.